But which team will Lee Johnson select for the clash against the Fratton Park club?
Here, we take a look ahead of the game on Wearside this coming weekend.
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1. GK: Thorben Hoffmann
The German loanee has returned to the squad after a bout of Covid in Sunderland's squad.
Photo: PHOTOGRAPH BY FRANK REID JPIMEDI
2. RB: Carl Winchester
A solid option at full-back for Lee Johnson.
Photo: PHOTOGRAPH BY FRANK REID JPIMEDI
3. CB: Bailey Wright
Brings leadership and experience to Sunderland's young squad.
Photo: FRANK REID 2021
4. CB: Callum Doyle
The Manchester City loanee has been a stalwart at centre-back for Sunderland this campaign.
Photo: FRANK REID PHOTOGRAPHER 2015