Top scorer Ross Stewart has been ruled out for Tony Mowbray’s side with a thigh injury, while defender Dennis Cirkin is also expected to miss the match with a hamstring issue.
Stewart’s absence will mean Sunderland have to alter their approach, while Mowbray may consider a change of formation after his side were beaten 1-0 at Middlesbrough last time out.
New signing Amad Diallo came off the bench to make his Black Cats debut at the Riverside, and could be in line for his first start.
Here’s our predicted Sunderland line-up to face Reading:
New signing Amad Diallo came off the bench to make his Black Cats debut at the Riverside, and could be in line for his first start.
5. CB: Aji Alese
With Dennis Cirkin expected to be sidelined for the next two matches, Alese, 21, is likely to receive an opportunity. Photo: Frank Reid
6. LWB: Jack Clarke
After an excellent performance against Rotherham, Clarke struggled against Middlesbrough but has performed well in the wing-back role this season. Photo: Martin Swinney
7. CM: Corry Evans
Sunderland's captain has been a key player so far this season while the squad lacks alternatives in the holding midfield role. Photo: Frank Reid
8. CM: Dan Neil
The midfielder has looked re-energised this season after dropping out of the team in the second half of the last campaign. Photo: Martin Swinney