The Black Cats have to win to stand a chance of finishing in the play-offs, while hoping either Coventry or Millwall drop points.
Sunderland did come from two goals down to draw 2-2 with Watford at the Stadium of Light last time out and have now taken 22 points from losing positions this season.
Mowbray still has several first-team players unavailable for the fixture against Preston, yet his side are on an eight-match unbeaten run.
Here’s our predicted line-up for the match:
9. CAM: Patrick Roberts
Scored a stunning equaliser against Watford, a goal which could prove crucial in the play-off race. Photo: Martin Swinney
10. LW: Jack Clarke
The winger has started 43 of the side’s 45 league games this season, scoring eight goals and providing 10 assists. Photo: Martin Swinney
11. ST: Joe Gelhardt
Returned to the starting XI against Huddersfrield and has now started Sunderland’s last three matches. Photo: Frank Reid