And ahead of the clash, Lee Johnson has some key decisions to make when it comes to team selection.
The likes of Bailey Wright and Denver Hume are expected to miss out while Jordan Jones and Aiden O’Brien will again be monitored.
But while squad depth is still somewhat thin, Johnson may be tempted to make some changes amid the hectic fixture schedule – which sees Sunderland face promotion-chasing Lincoln just days after the trip to Accrington.
So who could be in-line for a chance at the Wham Stadium, and who could be afforded a rest?
Our writer Mark Donnelly has picked his team for the game, with four changes from the side who triumphed over Tranmere Rovers at Wembley on Sunday.
What team would you name? Let us know on our Twitter page – @sunechosafc.
1. GK: Lee Burge
The stopper has been in fine form of late and is now one of the first names on the teamsheet. While other areas of the field may see things freshened-up, it would be a major surprise were Burge not to start against Stanley. Photo: FRANK REID 2019
2. RB: Max Power
Sunderland's skipper has played a variety of positions in recent weeks, but could again be asked to start at right-back in the North West. With Conor McLaughlin only just returning from injury it may be a case of safety first with him - meaning Power is likely to start. Photo: FRANK REID 2019
3. CB: Dion Sanderson
Cup-tied on Sunday but so impressive in recent weeks, Sanderson is expected to slot straight back into the starting line-up in place of the injured Tom Flanagan. Photo: Frank Reid
4. CB: Luke O'Nien
Mr Versatile himself, O'Nien has built-up a solid partnership with Sanderson in recent weeks and Lee Johnson is likely to continue with that pairing at Accrington. Photo: FRANK REID 2020