Promotion from League One is clearly the priority for Sunderland this season, and Johnson has used the cup competitions to rotate his side.
But with a quarter-final place up for grabs, there is a real opportunity to reach the latter stages.
Johnson will also be wary of two important away fixtures against Rotherham and Sheffield Wednesday which are coming up.
Sunderland dropped to fourth in League One, albeit with games in hand on most of the sides around them, following Saturday’s defeat by Charlton, putting extra importance on the next few league games.
The Black Cats have had several players sidelined through injury in recent weeks but are close to having a fully-fit squad again.
Here's the side we think could start against QPR:
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. Lee Johnson Safc 0-1 Cafc EFL1 Stadium of Light 23-10-2021. Picture by FRANK REID
Sunderland boss Lee Johnson. Photo: Frank Reid

. GK: Lee Burge
The keeper has fallen down the pecking order since Thorben Hoffmann's arrival but has received game time in cup competitions. Photo: JPI Media

5. LB: Denver Hume
Following his lengthy hamstring injury, the full-back made his first league appearance of the season against Crewe last week. This would be another step up. Photo: Frank Reid

6. CM: Corry Evans
Came off the bench against Charlton after recovering from a calf issue. Will be hoping to receive some game time after a spell on the sidelines. Photo: JPI Media

7. CM: Dan Neil
Didn't have his best game against Charlton but has still enjoyed an impressive start to the season and gives the side attacking impetus from midfield. Photo: JPI Media

8. RW: Lynden Gooch
Another player who is available again following an injury lay-off. Gooch came off the bench against Charlton after recovering from a foot issue. Photo: JPI Media