The Black Cats took an early lead when Ross Stewart was brought down by U’s defender Lloyd Jones, who was subsequently sent off.
Stewart then converted from the penalty spot before Elliot Embleton doubled the hosts’ advantage with a free-kick.
Cambridge pulled a goal back through Paul Digby, before Stewart added his second, while Nathan Broadhead and Danny Batth also got on the scoresheet.
Here is how the ‘data experts’ at FiveThirtyEight predict the 2021/22 League One table will finish and whether or not Sunderland will be in the playoff picture at the end of the campaign:
. Manager Alex Neil. Charlton Athletic FC 0-0 Sunderland AFC Efl1 05-03-22. Picture by FRANK REID
SAFC boss Alex Neil (Picture by FRANK REID) Photo: Frank Reid
. 24th: Crewe Alexandra
Crewe are predicted to finish 24th in League One with 30 points. Photo: Pete Norton
. 23rd: Doncaster Rovers
Doncaster Rovers are predicted to finish 23rd in League One with 38 points. Photo: Nathan Stirk
. 22nd: AFC Wimbledon
Wimbledon are predicted to finish 22nd in League One with 38 points. Photo: Christopher Lee
. 21st: Gillingham
Gillingham are predicted to finish 21st in League One with 41 points. Photo: Jacques Feeney
. 20th: Fleetwood Town
Fleetwood are predicted to finish 20t in League One with 42 points. Photo: Pete Norton
. 19th: Morecambe
Morecambe are predicted to finish 19th in League One with 43 points. Photo: Julian Finney
. 18th: Lincoln City
Lincoln are predicted to finish 18th in League One with 51 points. Photo: George Wood
. 17th: Shrewsbury Town
Shrewsbury are predicted to finish 17th in League One with 51 points. Photo: Clive Brunskill
. 16th: Burton Albion
Burton are predicted to finish 16th in League One with 54 points. Photo: Warren Little
1. 24th: Crewe Alexandra
Crewe are predicted to finish 24th in League One with 30 points. Photo: Pete Norton
2. 23rd: Doncaster Rovers
Doncaster Rovers are predicted to finish 23rd in League One with 38 points. Photo: Nathan Stirk
3. 22nd: AFC Wimbledon
Wimbledon are predicted to finish 22nd in League One with 38 points. Photo: Christopher Lee
4. 21st: Gillingham
Gillingham are predicted to finish 21st in League One with 41 points. Photo: Jacques Feeney