As we get into the spirit of the occasion, here are 11 reminders of encounters between the two sides spanning from 1972 to 2024.
There are some well known former Black Cats stars to spot. See how many you recognise.
In case you missed it;
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1. On the attack in 1972
Sunderland sub John Lathan fails to get on the end of a Dave Watson header against Oxford in 1972 - but Sunderland won the match 3-0. | se
2. Tueart and Porterfield
Dennis Tueart (right) beats keeper Burton for Sunderland's opener against Oxford as Ian Porterfield (left) looks on in 1972. | se
3. Snowy in 1975
A snowy Roker Park witnessed this 1-0 win against Oxford in December 1975. Tell us if you remember it. | se
4. The rush for tickets
Cup fever gripped Wearside when tickets went on sale for Sunderland's FA Cup clash at Oxford in 1992. | se