Sunderland v Tottenham Hotspur team news: David Moyes rings changes as AFCON stars return
Fabio Borini, Jack Rodwell, Lamine Kone, Didier Ndong and Javier Manquillo all come into the side, with Manquillo expected to replace van Aanholt at left-back.
Joleon Lescott is named on the bench, alongside Lynden Gooch who could make his return from injury. Steven Pienaar is also named on the bench.
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Hide AdMichel Vorm is in goal for the visitors, with Hugo Lloris missing out due to injury.
Sunderland XI: Mannone, Jones, O'Shea, Denayer, Kone, Manquillo; Rodwell, Larsson, Ndong; Borini, Defoe
Subs: Mika, Love, Lescott, Pienaar, Januzaj, Gooch, Honeyman
Spurs XI: Vorm, Walker, Alderweireld, Dier, Rose, Dembele, Wanyama, Dele, Eriksen, Son, Kane
Subs: Lopez, Carter-Vickers, Davies, Wimmer, Sissoko, Winks, Janssen