And Sunderland duo Jordan Pickford and Duncan Watmore will hope to feature.
The pair featured in the Young Lions' opening victory against Portugal last Thursday when Lewis Barker’s second-half strike handed the Young Lions a narrow 1-0 win.
With three games in five days boss Gareth Southgate may be forced to rotate his squad with Guinea up first before the Young Lions take on Paraguay on Wednesday and Japan on Friday.
Watch the Sunderland pair in training by watching this video recorded by the Football Association - including some stunning saves by Pickford.
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* We will have a full match report online at the final whistle.