The carriageway was closed between Junction 62 for Durham City and Junction 61 for Bowburn as police officers looked to deal with the incident.
A statement from Durham Constabulary said: “Police were called shortly before 4am, this morning following reports of a concerns for a woman on the A181 bridge over the A1(M).
“A full road closure was put in place at J62. Emergency services attended and the woman is now receiving the appropriate care.
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“The road has now reopened.”