The fight to avoid relegation to the Championship has stepped up a notch in the last fortnight, with Sunderland and Hull's unexpected revivals meaning just two points separate the bottom six sides in the table.
With fourteen games to go, there are set to be major twists and turns, and this weekend is no different.
So who plays who and how might it affect the table? Here's what you need to know...
CRYSTAL PALACE - Stoke City (A)
A tough trip to the Britannia will be the last thing Big Sam wanted after that humiliation at Sunderland's hands.
Stoke have recovered from a difficult start to the season and are back to their resilient best, but the Eagles look far better on the road than on home turf.
Allardyce is also likely to throw Luka Milivojevic and Mamadou Sakho into the fold in search of a boost, providing the former has his visa approved in time. Could that be enough to spark an unlikely result?
HULL - Arsenal (A)
Marco Silva has worked wonders since arriving at the KCOM Stadium, and odds on the Tigers avoiding the drop have been slashed in recent weeks.
But their away form remains very poor despite the best efforts of the new boss, and surely coming up against an Arsenal side out to put that Chelsea defeat behind them will be a bridge too far?
None of Hull's long-term injury concerns will be back for the game. Arsenal could be without a recognised right-back but do have Mohamed Elneny back from AFCON duty.
Prediction: Home win
SWANSEA CITY (H) V LEICESTER CITY
The game everyone will be keeping their eyes on this Sunday.
Leicester have hammered Swansea in recent games, the Swans unable to live with the speed of their counter-attacks. The arrival of Paul Clement has toughened them considerably, though, and few would bet against them sinking the Foxes this weekend. That would have huge ramifications for the rest of the season.
Prediction: Home win
MIDDLESBROUGH - Everton (H)
Without a league win since mid-December, Boro suffered January disappointment when moves for their top targets fell through.
Boss Aitor Karanka has taken them to Spain for warm weather training this week but they face a tall order in toppling an Everton who are starting to find real consistency under Ronald Koeman.
Bournemouth, not out of it yet according to many, also face a daunting visit from Man City
Prediction: Away win
SUNDERLAND - Southampton (H)
With Swansea or Leicester guaranteed to drop points, a draw for the Black Cats would keep that momentum building and leave them very much in touch.
With tough games against Everton & Man City on the horizon, however, just how big would three points be?
How the table would look (Points followed by goal difference)
Bournemouth 26 (-12)
Swansea 24 (-25)
Boro 21 (-8)
Leicester City 21 (-17)
Crystal Palace 20 (-13)
Sunderland 20 (-18)
Hull City (-25+)