Victor Anichebe starts for Sunderland with Fabio Borini dropping to the bench.
That is the only change for the Black Cats from the 2-0 defeat to Leicester in midweek, with Lee Cattermole keeping his place in midfield.
David de Gea misses out for the hosts, with Sergio Romero starting in goal.
Michael Carrick and Marcus Rashford are also on the bench for the visitors.
Sunderland XI: Pickford; Jones, Denayer, Kone, Oviedo; Larsson, Rodwell, Ndong, Cattermole; Defoe, Anichebe
Subs: Mannone, Djilobodji, Borini, Khazri, Manquillo, Pienaar, Gibson
Man Utd XI: Romero; Darmian, Bailly, Rojo, Shaw; Herrera, Fellaini, Poga; Mkhitaryan, Lingard, Ibrahimovic
Subs: Martial, Carrick, Blind, Rashford, Fosu-Mensah, Tuanzebe, Pereira