Robbie Stockdale and Billy McKinlay will take charge of Sunderland for the trip to Middlesbrough on Sunday.
Stockdale has been at the club since 2012 and has worked under a number of first team managers.
McKinlay, former assistant to David Moyes at Real Sociedad, has had stints in charge of Watford and Norweigan side Stabaek.
Moyes brought him to Wearside last year in a scouting capacity, but an illness to Simon Grayson's assistant Glynn Snodin saw him temporarily promoted to the first team coaching set-up.
The Black Cats are likely to make a permanent appointment during the international break, with Milwall the next visitors to the Stadium of Light on November 18th.
A club statement read: "Sunderland AFC have placed Billy McKinlay and Robbie Stockdale as joint caretaker managers ahead of this weekend’s Tees-Wear derby.
"The pair take temporary charge after Simon Grayson parted company with the Black Cats following last night’s draw with Bolton Wanderers at the Stadium of Light.
"A further announcement regarding the vacant manager’s position will be made in due course."