David Moyes has handed Adnan Januzaj and Papy Djilobodji their full Sunderland debuts against Middlesbrough in the Wear-Tees derby.
Fabio Borini misses out with a toe injury, so Manchester United loanee Januzaj comes into the starting line-up after coming on as a sub against Manchester City last weekend.
Djilobodji, an £8million summer signing from Chelsea, makes his full debut after Younes Kaboul's £3.5million departure to Watford this week.
As expected, Lamine Kone, who this week turned down a new contract offer, is not in the squad after complaining of a back injury less than 24-hours after rejecting the new deal.
New signing Steven Pienaar is among the subs, the 34-year-old has signed a one-year deal after a successful trial with the club.
Sunderland AFC (4-2-3-1): Mannone, van Aanholt, Djilobodji, O’Shea (C), McNair, Love, Rodwell, Gooch, Watmore, Januzaj, Defoe.
Subs: Pickford, Khazri, Lens, Pienaar, Asoro, T Robson, J Robson.
Middlesbrough FC (4-2-3-1): Guzan, Nsue, Barragan, Gibson, Friend (C), Forshaw, Clayton, Stuani, Ramirez, Downing, Negredo.
Subs: Dimi, Ayala, Baptiste, De Sart, Adomah, Fischer, Nugent.
Referee: Martin Atkinson (Bradford)