Jack Ross has handed Max Power and Jack Baldwin their full debuts for Sunderland at Kenilworth Road.
They replace Alim Ozturk and Luke O'Nien, who drop to the bench.
An injury to Donald Love means Bryan Oviedo steps up to the starting XI.
Lee Cattermole is on the bench.
Sunderland XI: McLaughlin; Matthews, Baldwin, Loovens, Oviedo; Mumba, Honeyman, Power; Maguire, Gooch, Maja
Subs: Molyneux, Embleton, Ozturk, O'Nien, Cattermole, Hume, Ruiter
Luton Town XI: Stech, Potts, McCormack, Pearson, Stacey, Hylton, Lee, Mpanzu, Grant, Collins, Sheehan
Subs: Justin, Bradley, Shinnie, Cornick, Jervis, Rea, Shea