Bryan Oviedo and Lee Cattermole return from injury to replace Jason Denayer and Victor Anichebe in the Sunderland starting XI.
Wahbi Khazri misses out entirely with the Black Cats set to match Arsenal's five man defence.
Kieran Gibbs plays for the hosts, but Laurent Koscielny misses out.
Sunderland XI: Pickford; Manquillo, Jones, O'Shea, Kone, Oviedo; Cattermole, Ndong, Larsson; Borini, Defoe
Subs: Mannone, Rodwell, Lescott, Love, Gibson, Januzaj, Gooch
Arsenal XI: Cech; Bellerin, Holding, Mustafi, Monreal, Gibbs; Xhaka, Ramsey, Ozil, Sanchez, Giroud
Subs: Gabriel, Ospina, Walcott, Iwobi, Welbeck, Coquelin, Elneny