Seaham Red Star and Sunderland RCA both face tests against non-Northern League clubs in the second round of the FA Vase.
Mark Collingwood’s Red Star will host Maltby Main, from South Yorkshire, while RCA travel to Hemsworth MW, from West Yorkshire.
The ties are expected to be played on Saturday, November 21.
Elsewhere, North Shields will begin their defence of the FA Vase with a home tie against Ashington, and Consett host Northern League Division Two leaders South Shields.
FA Vase second round ties involving Northern League clubs:
Seaham Red Star vs Maltby Main
Hemsworth MW vs Sunderland RCA
Consett vs South Shields
North Shields vs Ashington
Morpeth Town vs 1874 Northwich
Colne vs Newton Aycliffe
Northwich Manchester Villa or Whitley Bay vs Dunston UTS
Marske United vs Runcorn Linnets
Guisborough Town vs Team Northumbria