Carlos Edwards will miss a month of Sunderland's Premier League campaign, and this month's Carling Cup return to his former side Luton.
The winger injured his hamstring in Wednesday's 2-2 draw at Birmingham and scans have confirmed he faces a spell on the sidelines.
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Nyron: we must keep standards up.It means the Trinidad & Tobago international will miss this weekend's trip to Wigan, glamour games against Liverpool and Manchester United and probably the home game with Reading on September 15.
Keane said: "I should have taken Carlos off on Wednesday, but when you are behind late in the game you want him on the field because you know he can produce something.
"I must admit, I had a feeling he might pick up some kind of injury, and so it's proved. He's out for a month. Three games in a week is demanding for all clubs at the start of the season and we have paid for that with losing Carlos."
There were a few walking wounded after the 2-2 draw at St Andrew's but Keane hopes all will be fit for tomorrow.
Michael Chopra, Dickson Etuhu and debutant Roy O'Donovan all hobbled out of the ground on Wednesday.
Keane said: "That's football. You are going to get kicks and strains. Some of the players walk like that all the time. They're always limping!
"I think everyone will be OK and I left four players out on Wednesday – Anthony Stokes, Dwight Yorke, Kieran Richardson and Daryl Murphy – who are refreshed and available."
