Andy Welsh is hoping his side can extend their lead at the top of the Under-21 league to seven points with victory over Southampton on Sunday.
Sunderland have moved their last home match of the season to the Stadium of Light in the hope of boosting their Barclays Under-21 Premier League title prospects (12pm kick-off).
Welsh's side are currently four points clear of Manchester United, who have three games in hand over Sunderland.
But with the Red Devils not in action until Monday night when they host Chelsea at Old Trafford, Sunderland have the chance to extend their lead to seven points on Sunday afternoon.
Welsh said: "It will be great to play our final home game at the Stadium of Light and to hopefully secure another win which would take the title race right down to the wire."
Saints are seven points clear of the relegation places after back-to-back victories against Middlesbrough and Liverpool before the international break.
Sunderland season ticket holders get free admission.
Entry for non-season card holders is priced at £3 for adults and £1 for over 65s and under 16s, available via cash sales on the day of the game. Turnstiles 1-8 and 17-24 will open from 11am.