Ronald Koeman has warned his Southampton side to be wary of a backlash from Sunderland after the thrashing at Everton.
Sunderland were hit for six at Goodison Park, with Sam Allardyce looking for a big reaction from his players as they look to build on their last home game, the 3-0 derby day win over Newcastle United.
Saints boss Koeman is wary of a big response from the Black Cats and has warned his players to be at their best as they look to extend their best-ever start to a Premier League season in terms of away fixtures.
Koeman's men are chasing a sixth straight league match without defeat on the road.
But they will be without banned midfielder Victor Wanyama at the Stadium of Light on Saturday (KO 3pm).
Shane Long had closed in on a return after ankle trouble, but suffered a minor reaction in training on Wednesday and will now miss the Wearside trip also.
"Nobody is coming back," said Koeman.
"Shane and Jay (Rodriguez) are still out. Shane was close.
"He trained yesterday with the team but he's still not 100 per cent.
"So it's the same players, maybe the same team but without Wanyama.
"Victor's a miss because he's always starting normally, a key player, and that means that he's important for the team, in his defending from the midfield position."
Despite going five games without an away defeat this season, the Saints have only won one in 12 on the road, a contrasting statistic the Dutch boss hopes his side can quickly improve.
"If you don't lose away that gives everybody a good feeling," said Koeman.
"The feeling to be unbeaten until now, it's a good feeling.
"But if you count points maybe it's better to lose one and to win one.
"It was a long time ago that we won away, against Chelsea, and it's not always the performance that we expect of the team in our away games.
"Maybe that confidence can change this weekend, because we need a win."