Silksworth CW defend the Durham County FA Trophy they won last season, when they have home advantage over Stockton West End in tomorrow’s quarter-final (1.30pm).
But manager Sean Butler is unable to call on several players.
Vice-chairman David Steele said: “A number of the lads are cup-tied, having played for other clubs before joining us.
“Fortunately, Sean has Dean Randall, Nicky Smith, Mathew Bray and Jack Murphy available, so we’ll certainly give them a good game.”
Seaham Red Star Reserves’ tie with Wolviston will now be played at Metcalfe Park because the first team are at home to North Shields in the Northern League.
Manager Don Naylor is hopeful of making a couple of signings before kick-off and James Murphy is definitely available, but Kyle Bell will need his fitness assessed.
Spennymoor Town Reserves are at Durham Alliance Combination League high-fliers Coundon & Leeholme for their quarter-final, and manager Carl Beasley has a full squad on standby.
Hartlepool line up against another Alliance side, Sherburn Village WMC.
Midfielder Kieran Mitchell has joined from Silksworth CW and it’s expected that Callum Hudson, Craig Wetherill, Terry Wilkinson and Luke Hogan will also be named in a strong squad.
In the league, Ashbrooke Belford House face possibly their most difficult task of the season, when they visit Stockton Town, who are favourites to clinch the championship for a fourth consecutive season.
The Teessiders are second-top, five points behind leaders Redcar Athletic with as many games in hand.
Stockton boast a potent attacking force which has netted 73 goals in just 16 games. Just as importantly, they have conceded a miserly 14 times.
The statistics underline the challenge for Belford, who are sixth.
Joint Ashbrooke manager Asa Dobbing reports that David Scott, Nathan Burton, Shaun Petch, Jordan Birnie, Corey Steele and Iain Potts come into contention, but Stephen Halliday, Kevin Humble and Adam Hopps are banned.
Sunderland West End are fifth, ahead of their trip to Welfare Park to take on Horden CW.
A boost for the Wearsiders is the news that manager Anth Nelson could have a full squad to choose from. His only doubt is James Fryatt, who may have work commitments.
Leaders Redcar Athletic start favourites against out-of-form Annfield Plain.
The Seasiders definitely have Joe Blackburn in contention and James Swann and Danny Wray may also be able to play.
Plain have shipped goals recently and are now fifth-bottom with the third-worst defensive record. They are keeping their fingers crossed that Kieran Dowling, Aaron Shield and James Davies will have recovered from injuries.
Leam Rangers host Harton and Westoe CW, boosted by the inclusion of defenders Leon Kane and David Stevens and midfielder Graham Stephenson, who have completed bans.
Prudhoe Town include Liam Henderson, signed from Whickham, in their squad at home to Boldon CA.
Jarrow are in North Yorkshire for their match at Richmond Town and could have Kris Allen and Paul Trosh involved at some stage. The pair are making their comebacks following long injury lay-offs.
Definitely travelling are Mark Williams and Brodie Simpson, while Richmond have striker Sam Joyce itching to make his home debut after scoring twice when coming off the bench last weekend.
His brother Joe, who also recently signed for the club, may be involved and Michael Gunnell and Mark Edzes are hopeful of successfully coming through fitness checks.
Midfielder David Thorne, however, plays his last game before emigrating to Australia.