Redhouse Last Orders broke their duck in the new league, edging home 3-2 in a Sunderland derby thriller against Oddies.
John Smith, man of the match Michael McCabe and Jack Barnes came up trumps for Redhouse, with Oddies having Michael Bulmer and star man Luke Taylor on target.
Sherburn Village WMC showed no mercy in a 15-0 demolition of new club Washington AFC, with six-goal Glenn Hendrix particularly ruthless in front of goal.
Man of the match Joe Simpson added four goals, with Ben Reed, Mark Wild (2), Daniel Chester and Dan Rooney also notching.
Durham City drew 1-1 with Bishop Auckland Reserves, with star man James Huntley the home marksman.
Farringdon Detached went down 5-2 at Wallsend Town, while fellow newcomers Seaham New Westlea were overwhelmed 12-0 at Wheatley Hill WMC.
Killingworth YPC won 2-1 at Blackhill & Ebchester, after trailing to a Dan Parker header. Redcar Town earned the same result, 2-1 at Hartlepool Reserves, coming from a goal down at the break, thanks to Jamie Lee and Ryan Bennions. Sam Harrison netted for Pool.
On Monday night, Hall Farm maintained their superb form with an excellent 2-0 victory at Bishop Auckland Reserves, with Chris Bewick and sub Josh Tuckwell bagging the vital goals. Lee Pearce was man of the match, with Connor McEvoy best for Bishops.
Redhouse Last Orders found Coundon & Leeholme too strong, going down 5-0 despite a man-of-the-match display by Adam McQuillan.
Wheatley Hill WMC were outgunned 6-2 by Hartlepool Reserves, who had six different scorers, while Whitburn Village lost out 4-2 to visitors Blackhill & Ebchester, for whom Michael Hannant, Jack Sanderson, Dan Parker and Stephen Agnew all notched.
Wednesday results: Coundon & Leeholme 8 Blackhill & Ebchester 0, Farringdon Detached 1 Wheatley Hill WMC 1, Seaham New Westlea 1 Durham City Reserves 9, Washington AFC 1 Hall Farm 2