Forty-six Wearside and County Durham school staff have been suspended from work in the past three years, according to figures obtained by the Echo.
However, only 17 were disciplined or lost their job, with three cases still ongoing.
Pressure group Fact (Falsely Accused Teachers and Carers), said increasing numbers of misconduct allegations nationally, partly fuelled by a compensation culture, were seriously harming the profession.
In Sunderland, 11 school employees have been suspended in the past three years, with three dismissed, three disciplined and three resignations.
County Durham education authority has made 35 suspensions since 2005, which have led to six dismissals, one resignation and one mutual termination.
The Echo obtained the figures under the Freedom of Information Act.
However, neither council would name the schools involved or give details about the reasons staff had been sacked or suspended from duties, saying such information was of a personal nature and therefore exempt from disclosure.
Fact, which lobbies for changes to the criminal justice system, said itself and the teaching unions were entirely in agreement that all allegations should be investigated.
However, a spokeswoman said: "One of the main concerns is the length of time it takes to investigate a matter, during which time the teacher remains suspended.
"And, even if it is unproven, the allegation remains on a teacher's record, which is a huge bone of contention.
"There's no question it puts people off teaching. For men especially there is a permanent risk of facing allegations in the teaching profession."
On the possibility that some allegations were from parents out to make fast cash, the campaign group spokeswoman said: "There's no question that financial compensation is very significant now, compared to 10 years ago before the 'no win no fee' operations became available."
North East teachers who have faced action recently include Ian Graham, from Durham, who was banned from classrooms for three years for using sexual terms in lessons and being "over familiar" with female students.
A former English teacher at Houghton Kepier School, he was found guilty of unacceptable professional conduct by the General Teaching Council after his comments saw him sacked from Durham Gilesgate Sports College.
A Houghton Kepier technology teacher quit last year after accessing right-wing websites during school hours.
Former soldier Adam Walker, from Spennymoor, County Durham, left after being told he faced disciplinary action for viewing politically extreme sites.