His latest walk begins in Taunton, Somerset, where he began playing.
It will finish at Durham County Cricket Club's home at the Riverside, Chester-le-Street, and members of the public will be invited to join him on the final seven-mile stretch from Beamish.
The 52-year-old bowled his last ball in first class cricket at The Racecourse in Durham city.
Sir Ian, who lives near Barnard Castle, is once again walking in aid of the Leukaemia Research charity of which he is president.
He said: "When I first started walking to raise funds for children with leukaemia in 1985 the survival rate was 20 per cent.
"That has now risen to 80 per cent and I am determined to see all children survive in my lifetime.
"Join me on my 2008 walk and together we will help beat this terrible disease."
The walk begins on October 10 and will take in several towns including Windsor, Bury St Edmunds, Stratford, Llandudno, Harrogate and the outskirts of Glasgow before arriving at Chester-le-Street on October 18.
For the first time, a limited number of people will be able to walk with Sir Ian in exchange for sponsorship.
Marks and Spencer, Thistle Hotels and VW cars have agreed to provide food, accommodation and general support for the walk.
Sir Ian played for Worcestershire and England as well as Somerset and Durham and is now a television commentator for Sky Sports.
Members of the public wanting details of the walk can contact Georgina Fitt on 0207 269 9003, or via the internet: www.bothamwalk.com