The six Easington Community Science College pupils are set to explore the Amazon rainforest, the Arctic and the Himalayas as part of a British Schools Exploring Society (BSES) expedition.
But before they can pack their bags for the trip of a lifetime, they need help to raise £24,000 for travel and equipment.
If they are successful they will head to the wild environments this summer to conduct research on matters such as altitude sickness and food chains.
Amy Robson will be travelling to Ladakh, one of the most remote regions of the Indian Himalaya.
She said: "It's just unbelievable that we have been given this opportunity. We've had a car boot sale to raise money and we've sent out letters to local businesses to see if they can help."
The 15-year-old, of Easington Village, added: "I'm really looking forward to going. It's a great opportunity to go somewhere different and meet new people."
The Year 11 pupils are looking for help through donations, sponsorship, raffle prizes, travel costs and free or subsidised equipment.
The four- to five-week exhibition has a kit list including items such as walking boots and sleeping bags, depending on which remote environment they are travelling to.
Katie Brown, 16, will journey from her home in Easington Village to the Amazon as part of the expedition.
She said: "The BSES came to school to see if anyone was interested in taking part and interviewed those who were.
"I thought it was too good an opportunity to miss. I go to France every year with my family, but I have never been anywhere like the Amazon."
Once there, she will work alongside researchers and conservationists from the Wildlife Conservation Society and the Peruvian University of Amazonian Studies to contribute to the preservation of one of the last true remaining wilderness areas on Earth.
One of the group will also be travelling to Svalbard, a wilderness on the edge of the Arctic Ocean.
Jane Martin, assistant headteacher, said: "This is the opportunity of a lifetime for the girls. They have developed a real team spirit and have really helped each out with fund-raising."
The other girls set to explore the remote regions are Jessica Goodrum, 16, Terri Anne Cooper, 15, Sarah Emerson, 15, and Rachel Humphries, 15.
lAnyone interested in helping the girls can contact the school, tel: 527 0757.